Tottenham are in talks with AC Milan over a move for ex-Chelsea defender Fikayo Tomori.
The England international is one of a number of options Spurs are looking at ahead of Deadline Day.
Tottenham boss Ange Postecoglou has said the club are considering signing a defender before Monday's 11pm deadline.
Postecoglou's defence has been severely hindered by injuries throughout the current campaign, with Dragusin the latest player to be sidelined after limping off during the Europa League game against Elfsborg on Thursday.
Speaking on the fitness of his back four ahead of the upcoming clash against Brentford, live on Sky Sports this Sunday, Postecoglou said: "Still not sure, we'll let it settle down and get more information over the weekend. He's [Dragusin] obviously not available for this weekend.
"In terms of others, Djed Spence should be available for the weekend, Sergio Reguilon should be OK.
"Every time I think I see the light at the end of the tunnel it turns out to be an oncoming train."
On other players in the squad, the Spurs boss added: "They're all around 10 days' time, Vic [Guglielmo Vicario], [Brennan] Johnson, Destiny [Udogie], Wilson [Odobert], Timo [Werner]. [Cristian] Romero is a tricky one.
"There's still work to do but all those guys, apart from Dom [Solanke], [who's] a week behind, are all slated for the next week to 10 days.
"[With Romero] it's just a slow healer, looking at a week-to-week basis. He's been out a while, it's just taking time."
Sky Sports News' Michael Bridge speaking on the Transfer Show:
"There have been early discussions and we're not yet sure if it would be a permanent deal or a loan but Fikayo Tomori is one of a number of options Spurs are considering.
"Ange Postecoglou said to our reporter Gary Cotterill in Friday's press conference that they would consider a defender.
"Radu Dragusin hurt his knee on Thursday night, I don't think Cristian Romero is anywhere near returning and Micky van de Ven returned on Thursday but Spurs don't want this problem again with injuries at the back.
"So there could be potential cover and if it is Tomori that would be good cover."
Sky Sports' Paul Merson on the Transfer Show:
"I think there will be a lot of teams after Tomori. Man Utd could do with him and Arsenal could as well. Arsenal have two centre halves but you always say if one of them get injured, they're right up against it.
"Tomori could get in a lot of teams and will be well, well wanted by a lot of teams. One of them could be Aston Villa as well, who have just got a lorry load of money from the Jhon Duran deal, a £50m profit."
Bayern Munich forward Mathys Tel has rejected a move to Tottenham, according to Sky in Germany.
Sky Sports News understands Spurs and Bayern had reached a verbal agreement on a £50m deal.
But the teenager has reportedly turned down a move to Postecoglou's side and is more open to a loan deal.
There is interest from Arsenal, Aston Villa, Chelsea and Manchester United in the 19-year-old.
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